I do! The 4th hole at Painted desert, Las Vegas, which has ruined my card on more occasions than I care to remember. I have no idea why as it's around 190yd par 3 and a nice 6 iron. It just doesn't fit my eye and I invariably end up missing the green and getting some kind of hideous plugged lie in the face of a bunker or stuck under a rock or something! I played there today and managed to walk off with a par (lipped out for birdie), which felt like the best score in a nice 75. Who knows, maybe I'm starting to master this one and I'll have to wait and see what my next one will be!
So come on, own up, what's your nemesis?